Трихлорниорутений (1-)

Description

The product is the dimethylammonium salt of a chloro-bridged diruthenium complex with the chiral diphosphine ligand H₈-BINAP: [NH₂Me₂][{RuCl((S)-H₈-BINAP)}₂(μ-Cl)₃]. The full name is dichlorotri(μ-chloro)bis[(S)-(−)-2,2′-bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl]diruthenate(II) dimethylammonium. Red-brown powder. Purpose - asymmetric hydrogenation according to Noyori.

Basic Attributes

• CAS No: 944451-12-1
• Chemical formula: C88H80Cl5P4Ru2 C2H7N H
• Molecular weight: 1690 g/mol
• Accurate weight: 1692.26128
• PSA specifications: 12 Ų

Physico-chemical indicators

• Appearance: red-brown powder
• Melting point: above 100 °C (according to suppliers - with decomposition)
• Storage conditions: 2–8 °C

Structure and principle of operation

Two ruthenium(II) atoms are linked by three bridging chlorine atoms, each carrying one terminal chlorine and one chelated diphosphine. The ligand is H₈-BINAP, a partially hydrogenated analogue of BINAP, in which the naphthalene cores have been reduced to tetraline cores. This position uses the (S)-enantiomer, which determines the direction of asymmetric induction. The negative charge of the complex is compensated by the dimethylammonium cation. The chiral pocket formed by the four phenyl phosphorus groups determines from which side the prochiral substrate approaches the metal, and thus the configuration of the product.

Scope of application

• asymmetric hydrogenation of prochiral substrates on ruthenium using the Noyori methodology
• production of optically active alcohols and carboxylic acid derivatives for pharmaceutical syntheses
• work where a specific enantiomer of the product is required rather than a racemic mixture

Safety Information

• Transport codes: NONH for all types of transport - the cargo is not classified as dangerous
• WGK Germany: 3

Storage and handling

Storage in the refrigerator at 2–8 °C, sealed containers, dry inert atmosphere: ruthenium phosphine complexes are oxidized by oxygen with loss of catalytic activity, and free phosphine turns into phosphine oxide. Weighing - in a glove box or in a counterflow of inert gas. Class WGK Germany 3: do not pour residues and washing solutions down the drain; collect ruthenium-containing waste separately and send it for metal extraction.