Этилицин

Description

Ethylicin (S-ethylethanethiosulfonate) is an agricultural antibiotic (antibacterial 402), systemic fungicide, and broad-spectrum plant growth regulator used in many field crops in China.

Basic Attributes

• CAS No.: 682-91-7
• Chemical formula: C4H10O2S2
• Molecular weight: 154.25
• Exact weight: 154.012222
• NSC Number: 22422
• HS code: 2930909051
• PSA specifications: 67.8
• XLogP3: 1.32

Physico-chemical characteristics

• Density: 1.2±0.1 g/cm3
• Boiling point: 283.7±9.0 °C at 760 mm Hg. Art.
• Flash point: 125.4±18.7°C
• Refractive index: 1.489

Manufacturing method

Sodium sulfide is dissolved in water and sulfur is added in a 1:1 ratio, the reaction is carried out at 80-95 °C for 1 hour to obtain an aqueous solution of disodium disulfide. Next, the solution is alkylated with chloroethane at 75-90 °C and a pressure of 1.18×10⁵-1.37×10⁵ Pa, the ratio of disodium disulfide to chloroethane is 1:2; the mixture is passed through dichloroethane, cooled, settled and the water is separated to obtain diethyl disulfide. At the final stage, oxidation is carried out: 300 kg of diethyl disulfide and 10 kg of glacial acid are loaded into the reactor, the temperature is raised to 50 °C, 40% nitric acid is introduced dropwise at a molar ratio of diethyl disulfide: nitric acid = 1:1.33, the temperature is maintained at 50-60 °C at a negative pressure of about 9.6 × 10⁴ Pa for 30 minutes after adding the acid, then cool and separate the water - this is how antibacterial agent 402 (ethilicin) is obtained.

Scope of application

It is used to combat late blight of cotton and leaf spot of apple trees - two economically significant diseases, the suppression of which the declared activity of the drug is designed to suppress. The conventional name when entered into the grid is ethanesulfonothioacid, S-ethyl ether. As an agricultural antibiotic, ethilicin is a product of targeted chemical synthesis rather than microbial fermentation, which distinguishes it from biological antibiotics of plant protection. The chemical nature of the substance is a thiosulfonate ester; a sulfur-containing molecule of this class reacts with the thiol groups of proteins and enzymes of the pathogen, which explains the wide range of fungicidal and antibacterial effects.

Storage and transportation conditions

A flash point of 125.4±18.7 °C classifies the substance as a moderately flammable liquid - store away from sources of open flame, in a cool, dry room, in sealed original containers, separately from oxidizing agents and food products. When working with the concentrate, use gloves and respiratory protection, since the substance belongs to the class of thiosulfonates with a characteristic pungent odor of sulfur. Prepare working solutions immediately before use, avoiding prolonged contact with metal containers due to the corrosive activity of sulfur-containing compounds.