Фосфамидон

Description

Phosfamidon is an organophosphorus insecticide and acaricide of systemic action, vinyl ester of phosphoric acid. Classic brands - Dimekron 20, 50 and 100, Mercon, Kinadan. The drug is historical and strictly limited in circulation: liquid concentrates containing more than 1000 g/l of active substance are included in the Rotterdam Convention as particularly dangerous pesticide compounds; the substance is prohibited in many countries.

Basic Attributes

• CAS No: 13171-21-6
• Chemical formula: C10H19ClNO5P
• Molecular weight: 299.69; exact weight: 299.69
• EU number: 236-116-5
• HS code: 29241200
• PSA: 74.88000
• XLogP3: 0.86

Physico-chemical indicators

• Density: 1.2132 g/cm³ at 25 °C
• Melting point: −45 °C
• Boiling point: 162 °C at 1.5 Torr
• Flash point: 169.1 ± 27.9 °C
• Refractive index: 1.4718 (589.3 nm at 25 °C)
• Solubility in water: complete
• Hydrolysis: decomposes with alkali; Half-life at 73°F is 13.8 days at pH 7 and 2.2 days at pH 10
• Steam pressure: 2.2 × 10⁻³ Pa (25 °C)
• Storage conditions: 2–8 °C

Mechanism of action

Phosphamidone phosphorylates insect acetylcholinesterase and disables the enzyme from working. Acetylcholine ceases to be destroyed in the synapse, the nerve impulse continues continuously, overexcitation, paralysis and death occur. Complete solubility in water determines systemicity: the substance is absorbed by the roots and leaves and distributed throughout the vascular system of the plant, affecting hidden and sucking pests that are inaccessible to contact preparations.

Scope of application

• sucking pests: aphids, leafhoppers, thrips, mites
• crops of field and plantation farming according to historical regulations of application
• restriction: the drug belongs to the first hazard class, circulation is allowed only where it retains registration

Toxicity

• LD50 oral, rat: 8 mg/kg
• LD50 oral, mouse: 6 mg/kg

Safety Information

• Hazard Statements: H300 - fatal if swallowed; H311 - toxic in contact with skin; H341 - suspected genetic defect; H410 - very toxic to aquatic life with long lasting effects
• Precautions: P264, P273, P280, P301 + P310, P312, P501
• Hazard category: 6.1(a); Packing group II; transport code 3018
• Hazard class code: 24-28-50/53-68. Safety instructions: 23-36/37-45-60-61
• Tags: T+, N. RTECS number: TC2800000. WGK Germany: 3
• Flammability characteristics: easily ignites from an open flame; When heated, toxic oxides of nitrogen and phosphorus, as well as chloride gas, are released. The card in the same list indicates sulfur oxide, but there is no sulfur in the composition of C10H19ClNO5P - the item was transferred from the original dump as is

Storage and transportation

The warehouse is ventilated, dry, at low temperature; recommended mode 2–8 °C. Storage and transportation separately from food and feed. Work is carried out in a full set of personal protective equipment, including respiratory and skin protection. Flushes and residues are not discharged into water bodies and sewers: the substance is very toxic to aquatic organisms. An alkaline environment accelerates the decomposition of the drug - this is taken into account when neutralizing spills.