Бруссонин Б

Description

Broussonin B is a phenolic compound of the diphenylpropane class, isolated from the bark of the trunks of Broussonetia kanzinoki (paper mulberry, mulberry family) along with flavans and flavones. The structure is 4-[3-(4-hydroxyphenyl)propyl]-3-methoxyphenol.

Basic Attributes

• CAS No: 73731-86-9
• Chemical formula: C16H18O3
• Molecular Weight: 258.31232
• Exact weight: 258.125580
• PSA Specifications: 49.69000
• XLogP3: 3.65

Physico-chemical characteristics

• Density: 1.2±0.1 g/cm3
• Boiling point: 439.7±35.0 °C at 760 mm Hg. Art.
• Flash point: 219.7±25.9°C
• Refractive index: 1,600

Scope of application

Brussonine B is being actively studied as an object of pharmacological research. It has been shown to suppress adipocyte differentiation in the 3T3-L1 cell line and reduce fat accumulation in them, an anti-adipogenic effect that is of interest for the development of anti-obesity drugs. Together with brussonin A, an antiangiogenic effect has been described: both compounds block the VEGFR-2 signaling pathway and reduce the expression of β1 integrin, which suppresses the proliferation, migration and invasion of non-small cell lung cancer and ovarian cancer cells. Antioxidant, anti-inflammatory, antitumor, antiallergic and antidiabetic activities have been generally described for Broussonetia kazinoki extracts containing brussonine B. The commercial use of the substance is limited to the role of a reference standard and research object; it is not produced industrially in large quantities.

Substance class and origin

Broussonetia diphenylpropanes are related to diarylheptanoids (compounds of this kind are also known from ginger and turmeric) and are formed via a mixed polyketide-phenylpropanoid biosynthetic pathway; their accumulation in the plant bark is associated with a protective function. In the same bark, brussonine B is accompanied by the isomeric brussonin A and brussonin E: the compounds differ in the position of methoxy and hydroxy groups on the aromatic rings of the propane bridge at a similar molecular weight, which determines the difference in solubility and biological activity of each isomer.

Safety Information

The source data does not contain information about transport codes, hazard classes and GHS phrases for brussonine B - there is no public safety data sheet for a specific substance. When handling a little-studied organic compound, the general rules of laboratory hygiene apply: work with gloves, safety glasses, in a fume hood, avoid inhalation of dust and vapors.

Storage and transportation conditions

Store in an airtight container, in a cool, dry place away from light, away from oxidizing agents and strong acids/bases. There is no special transport marking for the substance; it is transported as a laboratory reagent. Isolation and purification of brussonine B is carried out by sequential extraction of crushed bark with organic solvents with chromatographic separation of fractions from accompanying flavans and flavones.