Гераниин

Description

Geraniin is a complex natural ellagitannin (a hydrolyzable polyphenol of the gallotannin-ellagitannin group), a widespread secondary metabolite in the plant world. The name comes from the genus Geranium, but the compound is also found in rambutan fruits (Nephelium lappaceum), plants of the genus Phyllanthus and a number of other taxa, where it performs a protective function and has pronounced antioxidant activity.

Basic Attributes

• CAS No.: 60976-49-0
• Chemical formula: C41H28O27
• English name: Geraniin
• Section: phenols
• Molecular weight (according to dump data): 180.15588
• Exact weight: 952.64
• HS code: 2932999099
• PSA Specifications: 450.25000
• XLogP3: -1.10150

Physico-chemical characteristics

• Density: 2.3±0.1 g/cm3
• Refractive index: 1.948

Synonyms

• Geraniin (b-form)
• NSC 359346
• 81856-90-8 (related CAS number)

Scope of application

Geraniin is one of the most studied ellagitannins of plant origin: it demonstrates pronounced antioxidant activity due to multiple phenolic hydroxyl groups (the high polar surface area of ​​PSA 450.25 reflects the saturation of the molecule with hydroxyls), as well as antihypertensive, antidiabetic, antiviral and antimicrobial effects in in vitro studies and in animal models. Serves as a marker compound for the standardization of plant extracts of Geranium, Phyllanthus and Nephelium, an object for studying the bioavailability and metabolism of ellagitannins, as well as a reference standard for the quantitative analysis of polyphenols by HPLC in pharmacognostic and food chemistry. The presence in the molecule of a hexahydroxydiphenoyl (ellagic) acid group, characteristic of ellagitannins, explains the ability of geraniin to be hydrolyzed in the intestines of humans and animals to ellagic acid and urostelins, metabolites to which part of the biological activity of the original compound is attributed. This is what makes geraniin the object of active research into the bioavailability and metabolism of ellagitannins in the pharmacology of natural compounds. As an analytical standard, the substance is also used in the development of methods for mass spectrometric profiling of the polyphenolic composition of fruit and vegetable raw materials of various origins.

Storage and transportation

Detailed data on GHS hazard classification and transport codes have not been published by manufacturers. Store as an analytical reagent in a cool, dry place, in the original sealed packaging, protected from light and moisture - polyphenolic structures of this type are prone to oxidation during long-term storage in air. The geraniin molecule contains a hexahydroxydiphenoyl (ellagic) fragment, which is hydrolyzed in the body to ellagic acid and urostelins, metabolites that are attributed to part of the biological activity of the original natural compound.