Сукцинат железа (2+)

Description

Iron(2+) succinate, iron(II) succinate is a salt of ferrous iron and succinic (butanedioic) acid. Refers to pharmaceutical substances of the group of iron preparations: anatomical-therapeutic-chemical classification code B - blood and hematopoietic organs. It is used as a source of ferrous iron for the prevention and treatment of iron deficiency anemia, along with iron sulfate, fumarate and gluconate.

Note on card details

The designation “ATC code” in the source card is an artifact of machine translation of the English ATC code; correct reading - ATC code (Anatomical Therapeutic Chemical Classification), group B.

Basic Attributes

• CAS No.: 10030-90-7
• Chemical formula according to the card: C4H6O4, Fe (iron(II) succinate, C4H4FeO4)
• Molecular Weight: 171.91716
• Exact weight: 171.94600
• EU number: 233-082-3
• UNII: 818ZYK7N91
• ATC code: B - blood and hematopoietic organs
• Catalog section: inorganic substances and compounds

Physico-chemical characteristics

• Boiling point: 236.1 °C at 760 mm Hg. Art.
• Flash point: 110.9 °C
• PSA (polar surface): 80.3

Pharmacological group and mechanism

Antianemic agent, ferrous iron preparation. Iron is necessary for the synthesis of hemoglobin; with its deficiency, hemoglobin production decreases and microcytic hypochromic anemia develops. Fe(2+) salts are absorbed in the duodenum and upper jejunum more efficiently than ferric iron compounds. In rat models of iron deficiency anemia, iron(II) succinate increased hemoglobin, erythrocyte count, hematocrit, mean erythrocyte volume, mean erythrocyte hemoglobin content and mean erythrocyte hemoglobin concentration, as well as serum ferritin and iron and transferrin saturation, while reducing total serum iron-binding capacity.

Suction

The degree of absorption depends on the form of salt, dose, mode of administration and the state of iron reserves in the body: with normal reserves, about 10–35% of the dose taken is absorbed, with iron deficiency - up to 95%.

Scope of application

• pharmaceutical substance for oral iron preparations
• prevention and treatment of iron deficiency anemia
• iron fortification of specialized foods and supplements
• analytical standard for quality control of iron preparations

Storage and transportation

The card does not contain GHS classifications, transport codes and WGK class. Ferrous salts are oxidized by atmospheric oxygen, especially in a humid environment: keep the container tightly closed, the warehouse dry, cool, protected from light. Work with dry substances should be carried out with dust protection. Store iron supplements out of the reach of children: an overdose of iron salts is dangerous.