Метогекситал натрия

What is this substance

Sodium methohexital (Methohexital sodium, CAS 309-36-4) is the sodium salt of methohexital, an ultra-short-acting barbiturate. Full name on the card: 2,4,6(1H,3H,5H)-pyrimidinetrione, 1-methyl-5-(1-methyl-2-pentin-1-yl)-5-(2-propen-1-yl)-, sodium salt. Composition according to the card: C14H18N2O3·Na. Trade names: Brevital sodium, Briketal sodium, Brevimital, methohexitone sodium.

Pharmacological group and purpose

Means for non-inhalation general anesthesia. Like other barbiturates, it potentiates the effect of GABA on GABA-A receptors, prolonging the opening of the chloride channel and suppressing the excitation of the central nervous system. It is used for induction of anesthesia, short interventions, anesthesiological support of electroconvulsive therapy. The sodium salt was chosen for its water solubility: the drug is produced in the form of a powder for preparing a solution. The substance is listed as a DEA Schedule IV controlled substance, code number 2264.

Basic attributes (vendor card)

• Molecular weight: 284.28600; exact weight: 284.11400
• EU number: 206-217-9
• DEA code number: 2264
• UN number: 3249
• DSSTox ID: DTXSID6026036
• NCI Thesaurus Code: C66117
• PSA: 57.69000
• XLogP3: 1.35910

Physico-chemical indicators

• Appearance: White powder (NTP, 1992)
• Melting point: 140–147°F, approximately 60–64°C (NTP, 1992)
• Boiling point: 382.1 °C at 760 mm Hg. Art.
• Flash point: 184.9 °C. A separate line of the card with a reference to NTP, 1992 indicates that there is no data on flash point and the substance is probably flammable - the contradiction in the original data was retained without correction
• Solubility in water: 100 mg/ml or greater at 66°F (about 19°C)
• Reactions with air and water: soluble in water
• Reactive group: amides and imides
• Reactivity profile: solutions are incompatible with silicone and acid (NTP, 1992)

Safety Information

• UN number: 3249, hazard category 6.1(b), packing level III
• Fire extinguishing: dry chemical powders, carbon dioxide or halon extinguishers (NTP, 1992)
• Isolation and evacuation according to ERG 151 (toxic non-flammable substances): isolation of the spill area of ​​at least 50 m in all directions for liquids and at least 25 m for solids; in case of leakage, the distance on the leeward side is increased; in case of fire involving a tank, wagon or tanker - isolation and evacuation to 800 m in all directions (ERG, 2016)
• Personal Protective Equipment: When weighing and diluting pure substance, use a NIOSH certified half mask with a combination organic vapor/acid gas/HEPA cartridge (NTP, 1992)

Spill response and storage

Small spillage: The solid material is moistened with water and transferred to a suitable container, the residue is collected with absorbent paper moistened with water. Contaminated clothing and paper are packaged in a vapor-permeable plastic bag for subsequent disposal. All contaminated surfaces are washed with a strong soap solution. Re-entry into the area is permitted after clearance has been confirmed by a responsible person.

Possession is subject to DEA Schedule IV controlled substance requirements under State and Federal regulations, 21 CFR Part 1300 et seq. The container is closed, away from acids and silicone materials with which the solutions are incompatible.