Хризообтусин

Description

Chrysoobtusin (CAS 70588-06-6) is an anthraquinone derivative, chemical formula C19H18O7.

Basic Attributes

• CAS No: 70588-06-6
• Chemical formula: C19H18O7
• Molecular Weight: 358.34202
• Exact weight: 358.34
• DSSTox ID: DTXSID30220870
• HS code: 2914690090
• PSA: 91.3
• XLogP3: 2.8

Physico-chemical characteristics

• Density: 1.3±0.1 g/cm3
• Melting point: 214–215 °C
• Flash point: 212.4±23.6°C
• Refractive index: 1.598
• Solubility in water: insoluble, 5.4×10⁻³ g/l at 25 °C

Substance class

Monodihydroxyanthraquinone derivative - 2-hydroxy-1,6,7,8-tetramethoxy-3-methylanthraquinone. Belongs to the group of anthraquinone compounds characteristic of Cassia tora seeds (Juemingzi).

Source and origin

It is isolated from the seeds of cassia torus (Semen Cassiae), a plant material that has long been used in traditional Chinese medicine.

Biological activity

Cassia tora seeds are traditionally used to protect the liver, improve vision and relieve constipation. In this regard, anthraquinone components of raw materials, including chrysoobtusin, are being studied for antitumor and antioxidant properties; antioxidant activity is considered as a basis for the use of such compounds in cosmetic formulations, and antimicrobial properties are considered as a prerequisite for their use as natural preservatives.

Scope of application

It is used in pharmacological and phytochemical studies as an object for studying anthraquinone derivatives of cassia seeds, as well as as a marker compound in the standardization of plant raw materials Semen Cassiae.

Storage and transportation

Store in a dry place, protected from light, in an airtight container, taking into account the moderate volatility of the compound (flash point 212.4±23.6 °C). Data on UN transport codes, hazard class and GHS phrases for the connection were not found in available sources and are not provided in order to avoid false information.

Practical significance

In addition to their pharmacological interest, the antioxidant and antimicrobial properties of anthraquinone derivatives of cassia, including chrysoobtusin, are considered as a basis for the development of formulations in the cosmetics and preservative industries, areas where plant anthraquinones serve as an alternative to synthetic preservatives.

Related raw material components

Cassia torus seeds contain a whole complex of related anthraquinone derivatives, of which chrysoobtusin is only one of the components; Isolation and study of individual compounds makes it possible to establish the share contribution of each of them to the effects on the liver and vision traditionally attributed to raw materials.

Analytical value

As an individual marker, chrysoobtusin is used in chemical control of the authenticity of Semen Cassiae raw materials - its quantitative determination makes it possible to distinguish genuine raw materials from fakes and evaluate the content of active substances in finished herbal preparations.