Гибридафнифиллин А

Description

Hybridaphniphylline A is the first of two described hybrids of Daphniphyllum alkaloid and iridoid. Source: dried stems and leaves of Daphniphyllum longeracemosum; The presence of the compound was also noted in the leaves of Daphniphyllum macropodum. Along with it, hybridafniphylline B and diaminoalkaloid daphniciclidine I were isolated from plant material.

The carbon skeleton of the compound includes ten fused rings and was not described among natural substances until its publication in 2013 in the journal Phytochemistry. The authors classified hybridafniphyllines as a new class of hybrid metabolites and suggested that assembly occurs via Diels–Alder cycloaddition. The structure and absolute configuration were confirmed by NMR, mass spectrometry and the exciton chirality method in circular dichroism.

Basic Attributes

• CAS No: 1467083-07-3
• Chemical formula: C37H47NO11
• Molecular Weight: 681.779
• Exact weight: 681.315
• PSA Specifications: 175
• XLogP3: −1.2

Physico-chemical behavior

The polar surface of 175 Ų and the negative logarithm of the distribution (XLogP3 −1.2) are characteristic of a highly oxidized molecule with a large number of hydroxyl and ester groups. Dissolution is carried out in methanol, DMSO or water-alcohol mixtures; Non-polar solvents are not suitable for use.

Purpose

• reference sample for HPLC and mass spectrometric analysis of alkaloids of the genus Daphniphyllum
• material for structural and chemical studies of hybrid natural compounds
• target for the complete synthesis of complex polycyclic frameworks
• test substance in primary biological screening programs

Storage and handling

Milligram packaging. The container is sealed, stored at low temperatures in the refrigerator or freezer, without light and moisture. Solutions are prepared before the experiment. Supplied as a reagent for scientific research, medical use is not intended.