Неолинин

Description

Neolinine is a diterpenoid alkaloid of the genus Aconitum. Systematic name: (1α,6α,14α,16β)-20-ethyl-4-(hydroxymethyl)-6,16-dimethoxy-aconitan-1,8,14-triol. In terms of its skeleton, it is an aconitane alkaloid of type C19, close to neolin. The compound was first isolated from Aconitum japonicum subsp. subcuneatum, also found in Aconitum carmichaelii Debx. Supplied as reference standard.

Basic Attributes

• CAS No: 112515-37-4
• Chemical formula: C23H37NO6
• Molecular weight: 423.5
• Exact weight: 423.2620879

Structure and its consequences

In the molecule, four oxygen-containing functions are free as hydroxyls (positions 1, 8, 14 and hydroxymethyl at C-4) and two are capped with methyl esters (positions 6 and 16). There are no ester residues - benzoyl and acetyl, characteristic of aconitine and mesaconitine - in the structure. Diether alkaloids of aconite are among the most toxic representatives of the group, and non-ether alkaloids, to which neolinin belongs in structure, differ markedly from them in properties.

Scope of application

• reference standard for monitoring the alkaloid composition of Aconitum raw materials using HPLC and UHPLC methods with high-resolution mass spectrometry
• marker compound in the study of metabolism and processing of aconite raw materials, including fermented forms
• chemotaxonomic studies of species of the genus Aconitum

Storage and handling

The dump contains only molecular characteristics; there is no data on melting and boiling points, density, solubility, toxicity and transport classification in the card, and they are not given here. Aconite alkaloids are pharmacologically active, so handling is carried out according to the rules for potent substances of an unknown hazard class: gloves, safety glasses, hanging in a fume hood, tightly closed containers, storage without light and moisture, limited access.