Пикразидин Т

Description

Picrasidine T is a dimeric alkaloid of the β-carboline series from the bark of Picrasma quassioides (Japanese quassia, family Simaroubaceae). The molecule combines two indole blocks: a β-carboline fragment with methoxy and hydroxy groups and a tetrahydroindolo[2,3-a]quinolysinium system. It is isolated from the plant in the form of hydrochloride and in the form of a racemic mixture.

Main attributes

• CAS No.: 113808-03-0
• Chemical formula: C28H25N4O4 (cation)
• Molecular weight: 481.532
• Exact weight: 481.188
• PSA specifications: 107
• XLogP3: 4.5

Origin and related compounds

Picrasidins S and T are isolated from the bark and root bark of Picrasma quassioides cultivated in Japan; both are obtained as hydrochlorides and in racemic form. The structure of picrasidine T was determined by spectral analysis using chemical evidence and published in Phytochemistry. The picrasidine series has more than twenty representatives; for some of them - picrasidines G, I and J - antitumor activity has been described, in particular, suppression of metastasis of squamous cell carcinoma of the head and neck for picrasidine J.

Area of application

• standard sample for analysis of the alkaloid profile of the bark of Picrasma quassioides
• reference compound in studies of dimeric β-carboline alkaloids
• material for comparative work on activity within the picrasidine series

Storage and handling

Solid substance, supplied in laboratory packaging. Keep in a tightly closed container in a cool, dry place, protected from light: condensed nitrogen-containing systems are photolabile. Wear gloves and goggles and avoid inhaling dust.