Пиперлотин А

Description

Piperlotine A is an amide alkaloid, 1-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propenyl]pyrrolidine. The first member of the piperlotin A–L series, isolated from the pepper plant Piper lolot. The structure is simpler than that of subsequent members of the series: the aromatic ring carries a single methoxy group in the para position, followed by a conjugated double bond of the E configuration and an amide group closed by a pyrrolidine ring. The only compound in the group for which the melting point is given on the card.

Basic Attributes

• CAS No: 389572-70-7
• Chemical formula: C14H17NO2
• Molecular Weight: 231.29028
• Exact weight: 231.126
• PSA specifications: 29.5
• XLogP3: 2.4
• Synonyms: Piperlotine A, 1-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propenyl]pyrrolidine

Physico-chemical characteristics

• Melting point: 117–118 °C

Activity studied

• pronounced suppression of platelet aggregation

Methanolic extract of Piper lolot inhibited platelet aggregation induced by arachidonic acid and platelet activating factor. Separation of the extract with stepwise activity control yielded twelve new amide alkaloids, of which piperlotin A was the first to be described.

Scope of application

• analytical standard for the determination of amides in pepper raw materials and extracts
• reference substance for HPLC and LC-MS methods
• test compound in hemostasis studies
• model structure when studying the dependence of activity on the number of methoxy groups in the aromatic ring

Storage and handling

Research grade reagent, typically greater than 95-98% HPLC purity. Store in a tightly closed container, in the dark and dry. Gloves and safety glasses are used, and work with the powder is carried out under traction. GHS classification, transport codes and toxicological data are not provided in the product card.