Раувоюнин Б

Description

Rauvoyunine B is a monoterpene indole alkaloid of the picraline type from the aerial parts of Rauvolfia yunnanensis Tsiang. Described together with rauvojunin C in a paper on new alkaloids of this species; the structure was established by spectroscopy methods. Rauvolfia yunnanensis belongs to the cucumber family (Apocynaceae) and grows in southwest China.

Basic Attributes

• CAS No: 1414883-82-1
• Chemical formula: C23H26N2O6
• Molecular weight: 426.5
• Exact weight: 426.17908655

Place in the series of plant alkaloids

A group of new indole alkaloids has been isolated from Rauvolfia yunnanensis. Rauvojunin A is a rare tetracyclic macroline type, rauvojunin B and C are picralin type. Rauvojunin C differs from B in the presence of a 3,4,5-trimethoxybenzoic acid residue, which is evident from the difference in gross formulas and molecular weights. Isolation was carried out according to the biological activity of the fractions, the immunosuppressive effect served as a guideline.

Activity studied

• in vitro cytotoxicity assessed in five human tumor cell lines
• Immunosuppressive activity has been described for alkaloids of this species

Application

• analytical standard for profiling alkaloids of the genus Rauvolfia
• material for structural studies of picraline alkaloids
• test object in pharmacological screening

Storage and handling

Research reagent in small packaging. Store in a tightly closed container in the cold, away from light. Hazard classification not established; indole alkaloids of rauwolfia are biologically active, so work is carried out with gloves and safety glasses with local exhaust, contact with skin and inhalation of dust are excluded.