Блюмеатин Б

Description

Blumeatin B is a natural flavonoid, dihydroquercetin dimethyl ether, isolated from the aerial parts of the plant Blumea balsamifera (Asteraceae), which is traditionally used in Southeast Asian herbal medicine as a source of essential oil and biologically active extracts. According to the chemical structure, it is (2R,3R)-3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one - a dihydroflavonol with two methoxy groups in positions 4' and 7 of the flavanone ring, which distinguishes it from fully hydroxylated dihydroquercetin (taxifolin).

Basic Attributes

• CAS No: 79995-67-8
• Chemical formula: C17H16O7
• Molecular Weight: 332.308
• Exact weight: 332.30
• PSA specifications: 105.45000
• XLogP3: 2.30

Physico-chemical characteristics

• Density: 1.4±0.1 g/cm3
• Melting point: 165-167 °C
• Boiling point: 627.8±55.0 °C at 760 mmHg.
• Flash point: 234.4±25.0°C
• Refractive index: 1.645

Biological activity

The flavonoid exhibits antioxidant activity and inhibits the enzyme xanthine oxidase (XO), which links the compound to the regulation of uric acid levels and the anti-gout activity of Blumea balsamifera plant extracts. Anti-inflammatory activity was also noted, studied in comparative studies of a series of related dihydroquercetin derivatives, where the structure of substituents (position and number of methoxy groups) significantly affects the strength of enzyme inhibition and antioxidant potential, which makes a number of related dihydroflavonols a convenient model for structure-activity studies.

Structural features and synthesis

The compound was also synthesized chemically as an object of research to establish and revise the structure of natural bluemeatin, which confirmed the absolute (2R,3R) configuration of the chiral center of the dihydroflavanone ring and made it possible to accurately compare the spectral data of the synthetic and natural samples.

Scope of application

Used as a reference standard in phytochemical studies of Blumea balsamifera and related species, in the standardization of plant extracts and in the development of dietary supplements with antioxidant and anti-inflammatory effects. It is used in laboratory practice for comparative analysis of the flavonoid composition of natural raw materials using HPLC methods and for assessing the anti-gout potential of herbal preparations based on the degree of xanthine oxidase inhibition in biochemical test systems.

Storage and transportation

Store in an airtight container, in a cool, dry place, protected from light, at a low temperature to slow down the oxidative degradation of the hydroxyl groups of the flavonoid. The substance has not been assigned a special UN transport code, the GHS classification is not published by manufacturers - transportation is carried out in its original packaging as a regular laboratory reagent without special requirements for the temperature conditions of transportation.