Субэллиптен G

Description

Subellipten G (subelliptenone G) is a natural oxygen-containing xanthone, the structure of which is 1,4,5-trihydroxyxanthone. The xanthone core carries three phenolic hydroxyl groups: two on the A ring (positions 1 and 4) and one on the C ring (position 5). The compound is isolated from the root bark of Garcinia subelliptica, hence the name; also found in raw materials of Garcinia hanburyi. Product form: high purity yellow powder for research work. Catalog section - xanthones.

Identification

• CAS No: 162473-22-5
• Chemical formula: C13H8O5
• Molecular weight: 244.19962; exact weight: 244.037
• Class: xanthones, simple oxidized derivatives
• Synonyms: Subelliptenone G, subelliptenone G, 1,4,5-trihydroxyxanton

Physico-chemical properties

• Appearance: yellow powder
• Density: 1.640 ± 0.06 g/cm³ (predicted value)
• Boiling point: 440.3 ± 45.0 °C (predicted value)
• PSA Specifications: 87
• XLogP3: 2.4

The polar surface of 87 at XLogP3 2.4 reflects the presence of three phenolic hydroxyls on a rigid, planar tricyclic backbone. The values ​​of density and boiling point in the card are calculated - there are no experimental data on them, which is typical for natural compounds produced in milligram packages. Working solutions are prepared in dimethyl sulfoxide, methanol, ethanol; The substance is poorly soluble in water; when alkalized, it goes into solution due to the deprotonation of phenolic groups.

Origin and receipt

The main source is the root bark of Garcinia subelliptica. The compound belongs to simple oxidized xanthones of this genus and is also found in raw materials of Garcinia hanburyi. The scheme for obtaining a commercial product includes the collection of plant material, extraction with an organic solvent and chromatographic purification; purity is confirmed by HPLC, NMR and mass spectrometry.

Activity studied

• Antioxidant activity is the most studied property of the compound; evaluated in the DPPH, ABTS and FRAP tests. Three phenolic hydroxyls provide the ability to donate a hydrogen atom to the radical.
• Antidiabetic activity.
• Antiplasmodial activity.

Scope of application

• Reference standard for phytochemical analysis: identification and quantification of xanthones in extracts of plants of the genus Garcinia by HPLC and LC-MS.
• Reagent for studies of antioxidant activity: positive control and comparison object in the DPPH, ABTS, FRAP tests.
• Starting compound for the semisynthesis of substituted xanthones: three phenolic hydroxyls provide sites for selective alkylation, acylation and prenylation.

Safety Information

The GHS classification, hazard statements, precautionary statements and transport data for this substance are not available on the original card. The product is supplied in quantities specific to analytical standards and scientific work and is intended for laboratory use. Handling - according to the general rules for working with organic substances of unknown toxicity: gloves, safety glasses, lab coat, all operations with powder under a hood.

Storage and handling

The conditions are determined by the polyphenolic nature of the compound. Phenolic hydroxyls are oxidized by atmospheric oxygen, especially in the light and at elevated pH, so the container must be sealed and preferably made of dark glass, stored at a low temperature, or for long periods in an inert atmosphere. Solutions in organic solvents are kept frozen and protected from repeated freeze-thaw cycles. The specific regime is specified using the batch passport from the supplier.