Хлорантолид Е

Substance identification

Chlorantholide E is a sesquiterpene lactone of the eudesmane type, isolated from the aerial part of the plant Chloranthus elatior (family Chloranthaceae, chloranthaceae). The compound is part of a series of six closely related lactones, chlorantholides A–F, obtained from an ethanol extract of this species. The synonym for the name is 9alpha-hydroxychlorantholide D, reflecting the structural relationship with chlorantholide D and the position of the additional hydroxyl group at the 9th atom.

Basic Attributes

• CAS No: 1372558-36-5
• Chemical formula: C15H18O5
• English name: Chlorantholide E
• Molecular Weight: 278.30
• Exact weight: 278.11542367
• Synonyms: Chlorantholide E; 9alpha-hydroxychlorantholide D

Class and structure

Refers to eudesmane sesquiterpene lactones - derivatives of the fifteen-carbon C15 skeleton, characteristic of the genus Chloranthus. The molecule contains a lactone (γ-butyrolactone) ring, characteristic of this group of secondary metabolites, and an additional hydroxyl function that distinguishes chlorantholide E from the related chlorantholide D. The five oxygen atoms in the formula indicate a lactone moiety plus hydroxyl and/or ketone groups in the molecule.

Botanical source and chemotaxonomy

The genus Chloranthus (family Chloranthaceae) is a well-known source of biologically active sesquiterpenoids: along with eudesmanolides (which include chlorantholide E), lindenanolides and unique dimeric lindanes were found in plants of this genus. The presence of such compounds is used in chemotaxonomic studies of the family.

Related compounds and their activities

For the structurally similar chlorantholide D, isolated from the same source, the literature describes antibacterial activity against a number of strains and an anti-inflammatory effect, which is relevant in the study of arthritis-like conditions. For chlorantholide E itself, no separate data on biological activity were found in open sources at the time of preparation of the material - the compound appears as a component of a series of natural lactones, used primarily as a reference standard in phytochemical and pharmacological studies.

Physico-chemical data

The supplier dump for the item only shows the molecular weight (278.30) and exact weight (278.11542367); data on density, melting and boiling points, solubility, refractive index, vapor pressure and toxicological parameters (LD50, GHS phrases, transport codes) are not in the original description and have not been published by the manufacturer - filling them with estimated or “typical” values ​​by analogy with other sesquiterpene lactones is not allowed.

Application

Used as an analytical and reference standard in studies of natural compounds of the genus Chloranthus: for comparison of chromatographic and spectral characteristics, confirmation of the structure of related metabolites, in screening panels for the biological activity of sesquiterpene lactones. No data on industrial, agricultural or pharmaceutical use in registered form was found.

Storage and transportation

No specific requirements for the conditions of storage and transportation of chlorantholide E were found in open sources. As with most comparators of natural origin, handling of the substance should avoid prolonged exposure to light, moisture and elevated temperatures; specific numerical parameters (temperature conditions, shelf life) were not published by the supplier and therefore are not given.