Сульфокостулид А

Description

Sulfocostulide A (sulfocostunolide A) is a sesquiterpene lactone with a sulfonic acid group from the roots of Saussurea lappa (costus, the modern accepted name of the species is Saussurea costus). The compound is described in the article “Two New Sesquiterpene Lactones with the Sulfonic Acid Group from Saussurea lappa”, Chemical and Pharmaceutical Bulletin, 2005, v. 53, no. 7, p. 841; in this work, its structure was established as 13-sulfo-dihydrosantamarin, a derivative of santamarin eudesmanolide. The paired compound from the same publication is sulfocostunolide B (13-sulfo-dihydroreynosine); both substances are isomeric and have the same gross formula and molecular weight.

Basic Attributes

• CAS No: 1016983-51-9
• Chemical formula: C15H20O5S
• English name: Sulfocostulide A (Sulfocostunolide A)
• Molecular Weight: 312.38
• Exact weight: 312.103
• DSSTox ID: DTXSID00780092

Characteristics

• PSA: 89
• XLogP3: 1.1

Structure

Eudesmanolide sesquiterpene skeleton with a γ-lactone ring. The sulfone group is located at C-13, where the exocyclic methylene group is located in the original α-methylene-γ-lactone; it occurs when a sulfite ion attaches to an activated double bond. The compound differs from sulfocostunolide B in the position of the hydroxyl group and the double bond in the decalin part of the framework, which separates the santamarin-reynosine pairs.

Source

Roots of Saussurea lappa, family Asteraceae. Costunolide, dehydrocostus lactone and other sesquiterpene lactones are isolated from the same raw materials; Costus roots are traditionally used in India, China and Japan.

Scope of application

• Analytical standard for standardization of Saussurea lappa extracts
• Reference substance for phytochemical profiling of costus roots
• Material for research in the chemistry of natural sesquiterpene lactones

Storage and handling

The hazard class, transport codes and storage mode are not indicated in the original card; melting point, density, solubility indicators and toxicological data are not available there and therefore are not given. Handling is the same as with a standard sample of a natural compound: sealed containers, protected from light and moisture, solutions are prepared immediately before analysis.

Synonyms

• Sulfocostulide A
• Sulfocostunolide A
• Sulfocostunolide A
• 13-Sulfo-dihydrosantamarin (according to original description)