Париж VII

Description

Paris VII is a steroidal saponin from the rhizomes of plants of the genus Paris (crow's eye). In the literature it appears as Paris saponin VII, chongluoside VII (Chonglou saponin VII), polyphyllin VII, dioscinin, saponin Tg, 17-hydroxyparis II. The aglycone is pennogenin, a spirostane steroid with an additional hydroxyl at C-17. The carbohydrate part is a branched tetrasaccharide: three rhamnose residues and one glucose residue. Raw materials: Rhizoma Paridis (rhizomes of Paris polyphylla, including var. yunnanensis) and rhizomes of Trillium tschonoskii.

Basic Attributes

• CAS No: 68124-04-9
• Chemical formula: C51H82O21
• Molecular Weight: 1031.196
• Exact weight: 1031.18
• HS code: 29329990
• PSA Specifications: 314.83000
• XLogP3: 4.91
• Density: 1.5 ± 0.1 g/cm³
• Melting point: 243–245 °C (with decomposition)
• Refractive index: 1.629

The polar surface area of ​​314.8 with a lipophilicity of 4.91 reflects the duality of the molecule: a hydrophobic steroid skeleton is connected to a highly polar carbohydrate block. Hence the surface activity and ability to integrate into cell membranes, characteristic of saponins.

Activity studied

• suppression of tumor cell proliferation and initiation of apoptosis
• inhibition of epithelial-mesenchymal transition and reduction of invasiveness of ovarian cancer cells; mechanism described—GSK-3β/β-catenin signaling pathway
• anti-inflammatory and antioxidant effect as part of the biologically active fraction of rhizomes

Raw materials Paris polyphylla var. yunnanensis is traditionally used as an anthelmintic, antimicrobial and antitumor agent; saponins are considered the main active fraction of these rhizomes.

Scope of application

The analytical standard for standardizing Rhizoma Paridis and preparations based on it is authenticity control, quantitative determination of the amount of saponins and individual polyphyllins. Reference compound in oncopharmacological studies, in work on the GSK-3β/β-catenin signaling pathway, in studying the mechanisms of apoptosis. Supplied in milligram portions.

Storage and handling

The glycosidic bond is sensitive to acids and moisture, so the substance is stored dry, in a tightly closed container, at a low temperature. Working solutions are usually prepared in DMSO immediately before the experiment. Saponins irritate mucous membranes and cause sneezing when dust is inhaled, so hanging is carried out under a hood, wearing gloves, goggles and respiratory protection. Suppliers do not provide a harmonized GHS classification for the substance.