Тенациссозид G

Description

Tenacissoside G is a C21-steroidal (polyoxypregnane) glycoside from the stems and roots of Marsdenia tenacissima. Another catalog name is tenacissimoside A. The aglycone belongs to the tenacigenin B series: a pregnane skeleton with an 8,14-epoxy bridge, an acetyl group at C-12 and a tigloyl residue (2-methyl-2-butenoyl) at C-11. At C-3, a disaccharide chain of methylated 2,6-dideoxy sugars is attached. It differs from tenacissoside I in the nature of the acyl substituent at C-11: tigloyl instead of benzoyl.

Basic Attributes

• CAS No: 191729-43-8
• Chemical Formula: C42H64O14
• Molecular weight: 792.9
• Exact weight: 792.429626
• PSA Specifications: 178.04000
• XLogP3: 5.01

Physico-chemical characteristics

• Density: 1.27
• Boiling point: 821.8 ± 65.0 °C at 760 mm Hg. Art.
• Flash point: 238.4 ± 27.8 °C
• Refractive index: 1.558

The given values ​​are calculated based on the structure of the molecule, as indicated by the uncertainty intervals; the glycoside decomposes when heated and does not boil.

Activity studied

Tenacissoside G is described as one of the main active components of Marsdenia tenacissima and is being studied as an antitumor agent. A separate area of ​​research is the reversal of multidrug resistance: the compound relieves the resistance of tumor cells associated with overexpression of P-glycoprotein. Plant extracts, in addition to their antitumor effect, have been studied for antibacterial and anti-inflammatory activity and their effect on the immune response; cultures showed suppression of the growth of cell lines A-549 and MCF-7.

Scope of application

• analytical standard for standardization of raw materials and preparations of Marsdenia tenacissima
• reference substance for HPLC and UHPLC-MS/MS methods, including quantitation in blood plasma
• reagent for preclinical studies of antitumor activity and mechanisms of multidrug resistance
• object of work on the pharmacokinetics and metabolism of C21-steroid glycosides

Storage and handling

The product is intended for scientific research and analytical control; it is not allowed for use in humans outside of research protocols. Keep the container tightly closed, protect from light, and store at a low temperature according to the batch passport. Ester groups at C-11 and C-12 are hydrolyzed in an alkaline environment. Wear gloves and safety glasses and avoid dust when weighing. The product card does not provide transport codes and GHS phrases.