Теветин Б

Description

Tevetin B is a cardiac glycoside of the cardenolide series from the seeds of Thevetia peruviana (Cascabela thevetia), a yellow oleander. The molecule consists of an aglycone identical to digitoxigenin and a trisaccharide chain at the 3rd position of the steroid core: glucose bound to glucose, and then 6-deoxy-3-O-methylglucose. Among the cardenolides of mature seeds, tevetin B is the predominant component.

Biological action

Like other cardenolides, the substance inhibits Na+/K+-dependent membrane adenosine triphosphatase. Suppression of the sodium-potassium pump changes the ion balance of the cardiomyocyte and increases the contractility of the heart muscle. This also determines the high toxicity: poisoning with yellow oleander seeds is severe, with heart rhythm disturbances.

Basic Attributes

• CAS No: 27127-79-3
• Chemical formula: C42H66O18
• Molecular weight: 859.0 g/mol
• Exact weight: 858.96
• UNII: H77H03L5LQ
• PSA specifications: 273 Å2
• Compound class: cardenolide trioside, steroidal glycoside
• Aglycone: digitoxigenin

Scope of application

• analytical standard for forensic chemical and toxicological studies: determination in blood serum by HPLC-MS/MS and polarization fluorescence immunoassay
• reference substance in phytochemical analysis of raw materials of Thevetia and related species
• object of pharmacological research of Na+/K+-ATPase inhibitors

Safety Information

Cardiac glycoside, a potent substance. Wear gloves and safety glasses, weigh in a fume hood, avoid inhaling dust and contact with skin and mucous membranes. Handling only in laboratory conditions by trained personnel.

Storage conditions

Store in a tightly closed container, protected from light and moisture, separate from food and feed. Remains should be handed over to a licensed waste management operator.