Тигогенин

Description

Tigogenin is a steroidal sapogenin of the spirostan series, (25R)-5α-spirostan-3β-ol. Aglycone of steroidal saponins, isolated from plants of the genus Dioscorea, as well as from technical raw materials based on Agave sisalana (hence the synonym “sisalagenin”). Saturated analogue of diosgenin: characterized by the absence of a double bond in the B ring, therefore obtained by hydrogenation of diosgenin. Serves as a starting block for the complete synthesis of steroid drugs.

Basic Attributes

• CAS No.: 77-60-1
• Chemical formula: C27H44O3
• Molecular weight: 416.64
• Exact weight: 416.64
• EU number: 201-041-9
• UNII: 4SMU15RR44
• HS code: 2932999099
• PSA specifications: 38.7
• XLogP3: 6.5

Physico-chemical characteristics

• Appearance: White microcrystalline powder
• Density: 1.1 ± 0.1 g/cm³
• Melting point: 205.5 °C
• Boiling point: 516.6 °C at 760 mm Hg. Art.
• Flash point: 266.2 ± 21.8 °C
• Refractive index: 1.552
• Specific rotation: -68° (c = 0.8 g/100 ml, chloroform)
• Solubility: insoluble in water, soluble in ethanol and chloroform

Scope of application

• intermediate product of the synthesis of steroid medicinal substances and hormones
• starting material for the preparation of spirostane derivatives and tigogenin glycosides
• analytical standard for the determination of sapogenins in plant materials of Dioscorea and Agave
• object of biochemical research: anti-inflammatory and antitumor effects, effects on bone tissue in models of osteoporosis, suppression of hyperuricemia have been studied

Safety Information

• Hazard category: 2.3
• RTECS number: WH1443500
• Stability: Stable at normal temperatures and pressures

Storage and handling

Store tightly closed in a cool, dry place. Keep the powder away from direct light and moisture. When hanging, use gloves, goggles and respiratory protection from dust.