Гарденоин Дж

Description

Gardenoin J is a cycloartane triterpene isolated from the exudate (resinous secretions) of Gardenia thailandica, a Thai species of the genus Gardenia of the Rubiaceae family. Belongs to a large group of triterpenoids with a C30-skeleton of the cycloartane type.

Basic Attributes

• CAS No: 1345109-46-7
• Chemical formula: C30H48O5
• English name: Gardenoin J
• Synonym: Gardenoin J
• Molecular weight: 488.7
• Exact weight: 488.35017463
• PSA Specifications: 77.76000

Physico-chemical characteristics

• Density: 1.14±0.1 g/cm3 (predicted value)
• Boiling point: 642.0±25.0 °C (predicted value)

Compound class and origin

Cycloartane triterpenes are a group of natural C30 compounds with a characteristic cyclopropane ring in the A ring of the steroid framework, widely distributed in plants and considered as a biosynthetic precursor of phytosterols. Gardenoin J was isolated from the resinous exudate of Gardenia thailandica and structurally belongs to a series of polyoxygenated cycloartanes that accumulate in this form along with other gardenenoins (A–I and further).

Biological activity

For cycloartane triterpenes of the genus Gardenia, a number of activities characteristic of this structural class have been described in the literature, including anti-inflammatory and cytotoxic potential; specific quantitative activity data directly for gardenenoin J are not provided in open sources, which makes the compound primarily an object of further pharmacological screening.

Scope of application

Practical application - scientific research: gardenenoin J is used as a reference standard for comparative phytochemical analysis of Gardenia thailandica exudate, as well as a sample for studying the structural diversity of cycloartane triterpenes of the genus Gardenia and constructing structure-activity relationships in this chemical group. The compound serves as a comparison sample for confirming the structure of new natural cycloartanes using NMR spectroscopy and high-resolution mass spectrometry, and is also used in methodological developments in column chromatography and preparative HPLC purification of resinous extracts of the genus Gardenia.

Cycloartans as a biosynthetic class

The cycloartane skeleton is formed by cyclization of 2,3-oxidosqualene with the participation of the enzyme cycloartenol synthase and serves as the starting point for the biosynthesis of phytosterols in higher plants - in this cycloartanes are fundamentally different from the lanostane pathway of sterol biosynthesis in fungi and animals. Multiple oxidation of the original cycloartenol leads to a variety of polyoxygenated derivatives, which include the Gardenia thailandica series of gardenenoins.

Storage and transportation

Store in original sealed packaging, in a cool, dry place, protected from light, at +2...+8 °C; The powder form allows longer storage at -20 °C. Transported at a controlled temperature without sudden changes, the batch is accompanied by a Certificate of Analysis (COA) confirming the purity of the substance using standard chromatographic methods.