Гидрофторид цетиламина

Description

Cetylamine hydrofluoride (Hetaflur, amino fluoride 242) is a salt of hexadecylamine and hydrofluoric acid, a representative of the class of amino fluorides used as a source of fluoride ion in oral hygiene products. Unlike inorganic fluorides (sodium fluoride, monofluorophosphate), amino fluorides, due to the long lipophilic alkyl chain, are better adsorbed on the surface of tooth enamel, forming a more uniform film and ensuring prolonged delivery of fluoride to the tooth tissues.

Basic Attributes

• CAS No.: 3151-59-5
• Chemical formula: C16H35N,FH
• English name: Cetylamine hydrofluoride
• Molecular weight: 261.462
• Exact weight: 261.283
• EU number: 221-588-7
• UNII: S58EH61Q1Y
• DSSTox ID: DTXSID1073315
• HS code: 2923900090
• PSA Specifications: 26.02
• XLogP3: 6.6594

Physico-chemical characteristics

• Boiling point: 321.8 °C at 760 mm Hg. Art.
• Flash point: 140.6 °C

Synonyms

1-Hexadecanamine, hydrofluoride; hexadecylamine, hydrofluoride; connection 242; Hetaflur; SKF 2208K; GA 242; Elmex sol; amine fluoride 242; AmF 242.

Mechanism of action

Due to the small doses of fluoride released, demineralization is suppressed while supporting the remineralization of tooth enamel. The aminofluoride nature of the substance provides surface-active properties: the molecule is oriented with its hydrophobic tail towards air/oil, and with its polar aminofluoride group towards the aqueous phase and enamel surface, forming a thin protective film.

Scope of application

Active ingredient in toothpastes and rinses for the prevention of caries (historical Elmex formulation and similar aminofluoride compounds), component of professional dental gels and varnishes with a high fluoride content. Amine fluorides are not approved by the FDA in the United States, but are used in a number of other countries; In the European Union, the substance is expressly authorized and regulated by Annex III of the EU Cosmetics Regulation following an assessment by the Scientific Committee for Consumer Safety (SCCS).

Regulatory status

As an ingredient in oral hygiene products, aminofluoride compounds undergo a separate safety assessment taking into account the total daily dose of fluoride, especially in children, therefore the concentration of cetylamine hydrofluoride in finished formulations is strictly standardized by the manufacturer of the toothpaste or mouthwash.

Storage

Store in a tightly closed container, in a cool, dry place, away from sources of open flame, taking into account a moderate flash point (140.6 °C). Data on density and solubility for this batch are not available in the dump.

Comparison with inorganic fluorides

Unlike sodium fluoride and sodium monofluorophosphate, which provide rapid but short-term contact of fluoride ion with the enamel, amino fluorides form a thin lipid film on the tooth surface, from which fluoride is gradually released, providing a longer protective effect with a comparable or lower total fluoride concentration in the composition.