Диэтаноламина гидрохлорид

Description

Diethanolamine hydrochloride is a salt of hydrochloric acid and diethanolamine, a secondary amino alcohol. Belongs to the reactive group of amines: it neutralizes bases and is capable of releasing free diethanolamine in aqueous solutions. Externally it is considered as a crystalline solid, soluble in water.

Converting the free amine into the hydrochloride form increases the stability of the substance during storage and simplifies dosing in aqueous technological solutions: the salt is less volatile and less prone to oxidation in air than the original diethanolamine, which is convenient when used as an intermediate product of multi-stage synthesis.

Diethanolamine, which is the basis of the salt, belongs to secondary alkanolamines and is widely used as an independent reagent, but it is the hydrochloride form that is in demand where a controlled, easily dosed source of protonated amine is needed without the risk of volatilization or carbonization in air.

Basic Attributes

• CAS No: 14426-21-2
• Chemical formula: C4H11NO2, ClH
• Molecular weight: 141.597
• EU number: 238-396-4
• UNII: OI45OUW092
• PSA Specifications: 52.49
• XLogP3: −0.2465

Physico-chemical characteristics

• Density: 1.24 g/cm3
• Melting point: −26 °C
• Boiling point: 239.4 °C at 760 mm Hg. Art.
• Flash point: 90.5 °C
• Refractive index: n20/D 1.517 (lit.)
• Steam pressure: 0.00104 mm Hg. Art. at 25 °C

Scope of application

It is used as an intermediate product in the synthesis of N-monophenylpiperazine and diethanolammonium chloride, as well as in the production of diethanolammonium-tetrachloropalladate(II) complex. It is used in detergents and cosmetic compositions as a reagent, surfactant and corrosion inhibitor in laboratory and industrial practice.

In synthetic practice, the salt is often a convenient entry point for the preparation of substituted piperazines and other nitrogen-containing heterocycles: the hydrochloride form simplifies the purification of intermediates by crystallization and reduces the risk of side reactions of the free amine with electrophilic reagents before the desired stage of the synthesis.

Safety Information

• WGK Germany: 1
• Hazard class code: R36/37/38
• Safety instructions: 26-37/39
• RTECS number: KL3500000

GHS classification

Signal word "Warning". H315 (100%): Causes skin irritation [corrosive/skin irritation warning]. Precautions: P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362. Aggregated GHS information provided by 447 companies from 1 notification to the ECHA C&L Register; Each notification may apply to multiple companies.

This broad consensus of the classification among hundreds of suppliers indicates a well-studied irritant profile of the substance: despite a single notification in the registry, it covers almost five hundred companies, which confirms the stability of this classification in the market.

It is also worth considering that the irritant effect (H315) refers specifically to the solid salt form of the substance; when diluted in aqueous solutions, the degree of irritation depends on the concentration and pH of the finished composition, therefore the final classification of the finished product is determined separately.

Storage and transportation conditions

Store in a tightly closed container in a cool, dry place, away from strong bases, to avoid release of free amine. Wear gloves and safety glasses and avoid contact with skin and mucous membranes due to irritant effects (H315).