Тридигексэтил

Description

Tridihexethyl is a synthetic anticholinergic drug from the group of quaternary ammonium compounds. The formula C21H36NO given in the card corresponds to the cation; its salts (chloride, iodide) were used in medicinal practice. According to the ATC classification, the substance has code A03AB08: anatomical group A - digestive tract and metabolism, therapeutic subgroup A03 - drugs for the treatment of functional disorders of the gastrointestinal tract, chemical subgroup A03AB - synthetic anticholinergics, quaternary ammonium compounds. The ATCvet veterinary code is QA03AB08.

Pharmacological group and indications

It was used as an adjuvant for peptic ulcers, as well as for acquired nystagmus.

Mechanism of action

Tridihexethyl binds to muscarinic acetylcholine receptors and is able to block all three of their types: M1 in the central nervous system and autonomic ganglia, M2 in the heart (influence of the vagus nerve), M3 in parasympathetic nerve-effector connections. Muscarinic receptors mediate several cellular responses through G proteins—inhibition of adenylate cyclase, degradation of phosphoinositides, and modulation of potassium channels. By blocking the action of acetylcholine, tridigexethyl suppresses reflexes transmitted through the vagus nerve, which leads to a decrease in the secretion of hydrochloric acid in the stomach.

Basic Attributes

• CAS No.: 60-49-1
• Chemical formula (cation): C21H36NO
• Molecular weight: 318.525
• Exact weight: 318.28
• DSSTox ID: DTXSID0048553
• ATC code: A03AB08; anatomical group A - digestive tract and metabolism
• ATCvet code: QA03AB08
• PSA specifications: 20.2
• XLogP3: 1.17

Physico-chemical properties

• Appearance: solid
• Melting point: 181.5 °C
• Solubility in water: 1.68 × 10⁻⁵ g/l

Features of Quaternary structure

The permanent positive charge on the nitrogen atom is not removed by changing the pH. For anticholinergics of this class, this structure is fundamental: the charged molecule does not pass through lipid barriers well, so the action is concentrated on peripheral muscarinic receptors, and penetration into the central nervous system is limited. The calculated XLogP3 1.17 and low polar surface 20.2 characterize the cationic part.

Storage and handling

The product is solid and melts at 181.5 °C. There is no data on the harmonized GHS classification, transport codes, labels and hazard phrases on the card - these items are taken from the batch’s safety data sheet. Quaternary ammonium salts are hygroscopic: keep the container tightly closed. Carry out work under a hood, wearing gloves and safety glasses, avoiding dust when hanging. The substance is pharmacologically active, so access to it is limited and taken into account separately.