Кобаламин

Description

Cobalamin is the common name for a group of cobalt-containing corrinoid compounds collectively known as vitamin B12, CAS 13408-78-1. The molecule is built on the basis of a corrin macrocycle with a central cobalt atom coordinated by a nucleotide loop with a 5,6-dimethylbenzimidazole base. Cobalamin is the only vitamin synthesized exclusively by microorganisms and containing a metal (cobalt) in the structure of the molecule.

Basic Attributes

• CAS No: 13408-78-1
• Chemical formula: C62H88CoN13O14P
• English name: Cobalamin
• Synonyms: cobinamide, dihydrogen phosphate (ester), internal salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole; related CAS 58846-82-5
• Molecular weight: 1355.37000
• Exact weight: 1354.57000
• EU number: 236-500-2
• HS code: 2936260000
• PSA Specifications: 487.66000
• XLogP3: 6.63228

Storage conditions (according to the supplier)

Store at 2–8 °C.

Substance class, structure and biological role

Cobalamin belongs to the class of corrinoids - derivatives of corrin, a tetrapyrrole macrocycle related to porphyrins, but with one direct linkage of pyrrole rings without a methylene bridge. Depending on the ligand coordinated to the cobalt atom, several forms of cobalamin are distinguished: cyanocobalamin (synthetic, stable form with a cyanide ligand), hydroxocobalamin, methylcobalamin and adenosylcobalamin (the last two are coenzyme, biologically active forms). Cobalamin is necessary for DNA synthesis, hematopoiesis (erythrocyte maturation) and the functioning of the nervous system - it participates as a coenzyme in the reactions of methyl group transfer (methionine synthase) and isomerization (methylmalonyl-CoA mutase).

Scope of application

It is used in pharmaceuticals and nutrition as an active ingredient in drugs for the treatment and prevention of B12-deficiency anemia and neurological disorders associated with vitamin B12 deficiency, as well as as a component of vitamin complexes and fortified foods. In laboratory practice, it is used as a standard sample and reagent for microbiological tests for vitamin B12 content.

Sources and Bioavailability

In nature, it is synthesized exclusively by bacteria and archaea; enters the human body with products of animal origin (meat, liver, fish, dairy products, eggs) or with products enriched with synthetic cyanocobalamin. Absorption in the intestine requires intrinsic factor Castle, produced by stomach cells.

Storage and transportation

Store at a temperature of 2–8 °C, protected from light, since cobalamins are sensitive to photodegradation. No special UN transport codes or hazard instructions are provided in the supplier’s passport data - the substance does not belong to the category of dangerous goods.

Identification

When accepting a batch, the CAS number 13408-78-1, EC number 236-500-2 and HS code 2936260000 are checked with the accompanying documentation; Related supplies may include the related CAS number 58846-82-5, which refers to closely related corrinoid structures.